What is the Endocannabinoid System & What Does It Do?
February 14, 2023
We all know that things feel a little different after we consume cannabis, but no two experiences are the same. A strain may make one person feel incredibly tired, while a different person may feel ready to take on the day. The differences in cannabis experiences are directly related to how cannabis interacts with our endocannabinoid system. This regulatory network is full of complexities we’re only just starting to learn more about.
What is the Endocannabinoid System?
You’ve likely seen a model of the nervous system, with little pathways going every which way from the center of our body out to our fingertips. But what if we told you there was an even more intricate network within the nervous system—along with our organs, muscle tissue, and more—that is responsible for anything from temperature regulation to learning and memory? That’s exactly what the endocannabinoid system is.
The endocannabinoid system, or ECS, is a complex network of endocannabinoids, receptors, and enzymes located throughout our body that control a variety of processes integral to not only our comfort but our survival. The ECS is responsible for keeping our bodies in a certain balance, or homeostasis, despite any internal or external factors we encounter.
What Does the Endocannabinoid System Do?
Now that you know what the endocannabinoid system is, it’s important to know what it does. The ECS actually has some big responsibilities, including the regulation and control of our mood, sleep, heart function, muscle and bone growth, and so much more. If there is a bodily function critical to both our day to day and our survival, chances are good the endocannabinoid system has something to do with it.
And it does all of this moderation with a singular goal in mind—keep our bodies in homeostasis. If something throws you out of sync—a lack of sleep, a slip and twist of the ankle, the sudden need for a 3 PM snack—it’s your endocannabinoid system that activates to try and re-regulate your body, so it can operate at its most efficient levels.
How Does the Endocannabinoid System Work?
The endocannabinoid system is made up of three integral parts:
- Endocannabinoids
- Endocannabinoid receptors (CB1 and CB2 mainly)
- Endocannabinoid Enzymes.
Throughout your entire body, the little receptors in the ECS activate based on different stimuli. The most basic example of this is when you get hot, your ECS fires off to re-regulate your body temperature by sweating or other means. So what activates them? Endocannabinoids. These are our self-made cannabinoids (as opposed to phytocannabinoids, or plant-made cannabinoids, created by the cannabis plant we know and love). When something happens that requires our body’s response, it creates the endocannabinoids that then activate the receptors, which help us to adjust to whatever situation we’re facing.
So what about the enzymes? The enzymes in the ECS are the clean-up crew. Once our body has created the endocannabinoids, and those little molecules have activated the receptors they need to activate to create the necessary response in our body, it’s time for them to go. Enzymes then come along and break down the endocannabinoids now that they’ve done their job.
Why is the Endocannabinoid System Important?
The endocannabinoid system is our body’s natural way of regulating itself and responding to both internal and external influences. It could be a hot yoga room that causes your body to sweat, or something more serious, like the natural destruction of cancerous cells. Because researchers know the ECS plays such a fundamental role in important functions within our bodies, they hypothesize that we could potentially affect the ECS to cause certain reactions, thereby treating things like chronic pain or even PTSD. The challenge is that we need a lot more research to truly understand the complexities of our endocannabinoid system. After all, we’re still discovering additional cannabinoid receptors.
Understanding the Endocannabinoid System and CBD
It’s possible that the lay-people who understand the endocannabinoid system better than anyone else are cannabis enthusiasts. That’s because phytocannabinoids (the ones made by marijuana), like endocannabinoids (the ones made by our bodies), can react with the receptors in our body in similar ways and create unique experiences for the consumer.
CBD (cannabidiol) is one of the more than one hundred cannabinoids found in marijuana, and probably the most well-known cannabinoid that isn’t psychoactive. But that doesn’t mean it doesn’t have a really interesting effect on the ECS.
CBD, unlike THC, doesn’t really bind with our endocannabinoid receptors (specifically, CB1 and CB2). Instead, it seems to increase the time our natural cannabinoids are in contact with our cells, causing them to fire off and create an elevated response within our bodies. Additionally, it seems to run interference with the CB1 receptor, almost like dulling its signal. This is why some marijuana consumers insist that strains with CBD tend to create a more moderate experience compared to products high in THC and minimal (if any) CBD.
Finally, while CBD may not specifically bind to the CB2 receptor, it does seem to amplify the CB2 receptor’s signal. Research indicates CB2 receptors help to regulate things like inflammation and immune responses within the body, so it’s possible CBD could, one day, be a catalyst in the treatment of inflammatory conditions.
Just remember, we’re a long way off from knowing exactly what CBD can and cannot do in the body, and moreover, how CBD may help in the treatment of different ailments.
Understanding the Endocannabinoid System and THC
So what happens, then, when you introduce a psychoactive cannabinoid, like THC, to the endocannabinoid system? While CBD doesn’t seem to bind to the receptors in our body, THC becomes good friends with our receptors—specifically CB1. CB1 receptors are more commonly found in our brain among other places. This is likely why THC causes its psychoactive effects, but it’s also why researchers are trying to understand if it could also be an important tool in treating conditions that affect memory, mood, appetite, motor control, and more.
Like with CBD, we’re a long way from being able to definitively say anything, but just the fact that it affects the endocannabinoid system is worth looking into and understanding better.
Understanding the Endocannabinoid System and CBN
CBN, cannabinol, is a lesser known cannabinoid created as cannabis ages and the THC within the plant breaks down. This can happen due to time and exposure to heat and light. CBN has some mild psychoactive effects (though this seems to be up for debate), and it also interacts with the ECS receptors in the body. Though, while THC gravitates toward the CB1 receptor, CBN seems to prefer CB2 receptors. This unique interaction of a THC metabolite has led to it being the subject of a number of studies trying to understand if CBN could have therapeutic value in treating certain conditions.
Of course, if studies are limited with THC and CBD, you can be sure that we are even less informed about CBN. Much more research needs to be done to understand if CBN actually has any therapeutic properties.
Answering Endocannabinoid System FAQs
There’s a lot of science involved with the endocannabinoid system, and the thing is, we barely understand it even with all the research we have done. So it’s no surprise that we get questions about it. Here are some of our most popular questions and their answers:
Does THC affect the endocannabinoid system?
Yes, THC’s effect on the endocannabinoid system is what creates the psychoactive experience the cannabinoid is known for.
Does CBD affect the endocannabinoid system?
Yes, CBD affects the endocannabinoid system in three ways: it interferes with signals sent to CB1 receptors, it amplifies signals sent to CB2 receptors, and it may also increase the time our naturally occurring endocannabinoids can interact with cells in our body.
What stimulates the endocannabinoid system?
Taking a cannabreak but still want to fire up your ECS? There’s a number of ways you can do that, including eating foods rich in omega-3 and -6 oils, indulging in chocolate (especially dark chocolate), sipping on certain teas, exercising, and even hanging out with friends. In general, if it helps your body get the nutrients it needs, reduces your stress levels, or just makes you happy, there’s a good chance it’s helping to stimulate—and may even strengthen—your endocannabinoid system.
Create Your Own ECS Experience
One of the fun things about being a cannabis enthusiast is that you can read about things like the endocannabinoid system, and then view our menu, head to one of our locations, pick up your favorite strain, and experience things for yourself. Our budtenders can help you find all different types of cannabis products—with varying levels of THC, CBD, and even CBN—but just remember, go slow and low so as not to overwhelm your ECS.
This content is not intended as medical advice. The information provided is meant to encourage cannabis education, not replace direct patient-healthcare professional relationships. Always consult your primary care physician or other healthcare provider prior to using cannabis products for treatment of a medical condition. Any statements contained herein have not been evaluated by the Food and Drug Administration. Products referenced are not intended to diagnose, treat, cure, or prevent any disease. Products are only available where consumption of cannabis is legal.
Related posts
Cannabis concentrates are very popular for their potency, flavor, and versatility, and live resin and distillate are among the most common types of concentrates. But which one should you choose? It’s important to understand their unique characteristics and how they’re made when choosing the right product for you.
In this guide, we’ll explore the key differences between live resin vs distillate, from their extraction methods to how they impact your cannabis experience.
What Is Live Resin?
While bongs use water to cool the smoke, some cannabis connoisseurs still find the experience harsh, especially on the throat.1 This is where ice comes in handy. Adding ice in a bong further cools down the smoke, giving you smoother hits. Some cannabis consumers believe that adding ice offers extra filtration, but there isn’t any scientific evidence to back that up. The cooler smoke can make the overall experience more pleasant, allowing for bigger inhales without the irritation that warmer smoke sometimes causes.2
What Is an Ice Bong
An ice bong is essentially a regular bong but with one key difference. There’s a built-in ice catcher, sometimes called an ice pinch. This is a small indent inside the neck (also called the downtube) of the bong, near the mouthpiece, that holds ice cubes above the water chamber.3 The ice cools the smoke as it rises through the downtube, making for a smoother, cooler hit. It’s perfect for cannasseurs who love a classic bong experience but want to make it even more comfortable on their throat and lungs.4
How Do You Use An Ice Bong?
Using an ice bong is easy, and it only takes a few extra steps compared to a regular bong5:
- An ice pinch: First, check to see if your bong has an ice pinch. You’ll know that your bong has an ice catcher if you can see tiny indentations on the neck.
- Add water: Like with any other bong, fill the water chamber first. Ensure the water level is appropriate for the downstem and the melted ice.
- Add ice: Slowly drop a few ice cubes into the ice catcher. Be careful not to overload or chip the glass. The ice will rest above the water, cooling the smoke as it travels up the downtube.
- Inhale as usual: Pack your flower into the bowl, light it up, and enjoy the extra-smooth hit. The cooled smoke will feel gentler on your throat, giving you a more enjoyable experience overall.
What Is a Freeze Bong?
A freeze bong is sometimes referred to as a glycerin bong because of the unique feature that sets it apart: a glycerin coil. Glycerin is a non-toxic, freezable substance that doesn’t expand when frozen, making it ideal for bongs. The glycerin coil sits inside the bong’s neck and chills the smoke as it passes through, similar to an ice bong, but without the need for ice. It’s a great alternative for those who want a cold, smooth hit but don’t want to deal with melting ice.6
How Do You Use a Glycerin Bong?
Using a glycerin bong is a bit different from an ice bong, but it’s just as simple:
- Freeze the coil: Detach the glycerin coil from the bong and place it in the freezer for about 45 minutes or longer. The glycerin cools quickly and stays cold for a long time, so there’s no need to freeze the entire bong (which can cause the glass to crack and reduce its insulation properties).
- Add fresh water: Pour enough water into the chamber to cover the downstem.
- Grind and pack flower: Grind your cannabis flower and pack it into the bowl.
- Reassemble the bong: Once the coil is frozen, reattach it to the bong and proceed as you would with a standard water pipe. It’s time to light the flower.
- Enjoy a cooler hit: The glycerin coil will cool the smoke as it travels through the bong, giving you a smoother, chill hit without fussing with ice cubes.
Other Ways to Cool Your Bong
If you’re not ready to invest in an ice bong or glycerin bong, there are other ways to get that cooler hit you’re after:7
- Ice water: Instead of placing ice cubes in the ice catcher, try using cold water in the base of your bong.
- Add ice to the water: Some people like to add ice cubes directly into the water chamber. While it’s not the same as using an ice bong, it can still help cool the smoke a bit more.
- Bubbler: A bubbler is a smaller, portable water pipe that can offer a cooler hit, similar to a bong, but without the bulk.
- Glycerin coil: If you don’t have a full glycerin bong, you can buy a separate glycerin coil that fits into the downtube of your existing bong.
Additional Considerations
While cooler smoke may feel more pleasant, there are a few things to keep in mind:
- Stronger hits: Because cooler smoke is easier on your throat, you might inhale more, which could lead to stronger effects. Be mindful of this when trying out an ice bong or glycerin bong for the first time.
- Lung irritation: Even though the smoke is cooler, you should avoid holding it in for too long. This can irritate your lungs regardless of the temperature.8
- No extra filtration: While some people think adding ice to a bong provides extra filtration, this hasn’t been proven. The cooling effects are real, but the ice doesn’t give your lungs any additional protection.9
FAQs About Ice Bongs
Wondering if an ice catcher bong is right for you? We’ve answered some of the most common questions below, but feel free to ask a LivWell budtender for more advice!
Does ice make bong smoking healthier?
There’s no evidence that ice adds extra filtration. While it cools the smoke, it doesn’t necessarily make it healthier.
What’s the difference between a bong and an ice bong?
An ice bong has an ice catcher or ice pinch, allowing you to add ice cubes to the neck of the bong for a cooler hit.
Do you have to freeze a glycerin bong?
The glycerin coil must be placed in the freezer for 45-60 minutes to get cold. Once frozen, it cools the smoke as you inhale, similar to how ice cools smoke in an ice bong.
Purchasing Freeze or Ice Bongs
Looking to upgrade your smoking experience? Whether you’re after an ice bong or a glycerin bong, LivWell dispensaries carry a variety of bongs and accessories to suit your needs. Stop by and chat with a budtender to find the perfect piece to make your next session smoother and cooler than ever.
Sources:
1. “Cannabis 101: Does the Ice in a Bong Trick Really Work?” Nuggmd, April 1, 2024, https://www.nuggmd.com/blog/cannabis-101-ice-in-a-bong
2. “Why Do People Put Ice in a Bong?” DailyHighClub, August 25, 2021, https://dailyhighclub.com/blogs/news/why-do-people-put-ice-in-a-bong
3. “How Do Bongs Work, and How Do You Use One?” Leafwell, https://leafwell.com/blog/how-do-bongs-work/
4. “How to Get Better Bong Rips… Super Easily!” WayofLeaf, May 14, 2024, https://wayofleaf.com/cannabis/lifestyle/ways-to-get-better-bong-rips/
5. “Should you put ice in your bong?” Cannigma, https://cannigma.com/how-to/should-you-put-ice-in-your-bong/
6. “Why You Need a Glycerin Bong,” DailyHighClub, February 2, 2024, https://dailyhighclub.com/blogs/guides/why-you-need-a-glycerin-bong
7. “Top 12 bong water alternatives to make weed taste better,” Canna Connection, June 14, 2022, https://www.cannaconnection.com/blog/11643-top-10-bong-water-alternatives-make-your-weed-taste-better
8. “Demystifying the Bong, One Myth at a Time,” Healthline, August 26, 2019, https://www.healthline.com/health/how-does-a-bong-work#comparison-to-other-methods
9. “Why Are Bongs So Strong? Here’s the Science Behind the Rip,” MIC, May 28, 2021, https://www.mic.com/articles/134389/why-are-bongs-so-strong-here-s-the-science-behind-the-rip
Please consume responsibly. This product may cause impairment and may be habit forming. There may be health risks associated with consumption of this product. State laws impact what dispensaries can and can’t sell to recreational customers and medical marijuana patients. Not every type of product, consumption method, dosage form, or potency mentioned on this blog will be permitted in all locations.
When you buy medical marijuana, it’s important to understand the laws in your state, how to get a medical marijuana card, and where to find a certified medical marijuana dispensary. Whether you’re in Colorado, Michigan, or any other state with a medical cannabis program, knowing your area’s specific requirements, legal limits, and approved conditions ensures that you stay compliant and can access the products that best meet your needs.
In this article, we’ll explore medical marijuana and guide you through the process of purchasing medical cannabis to make your experience as smooth and stress-free as possible.
What Is Medical Marijuana?
Medical marijuana or medical cannabis refers to the use of compounds derived from the cannabis plant, such as THC and CBD, to treat symptoms or conditions like chronic pain, nausea, and muscle spasms.1 Many patients use medical cannabis to potentially help manage symptoms of conditions such as Crohn’s disease, HIV/AIDS, irritable bowel syndrome (IBS), Parkinson’s disease, multiple sclerosis,2 post-traumatic stress disorder (PTSD), wasting syndrome,3 as well as side effects from chemotherapy and other cancer treatments.4 Because of the therapeutic potential of medical marijuana, it's been legalized in many states for medicinal use, offering a natural alternative for those seeking relief from debilitating symptoms.
What Is a Medical Marijuana Card?
A medical marijuana card is a state-issued ID that allows qualified patients to legally purchase medical cannabis. Each state with a medical cannabis program has its own process for obtaining a card.5 Generally, it requires a physician’s certification and registration with the state in which you reside. For example, if you need to get a card in Colorado, you’ll need to follow the specific application process outlined by the state, including providing proof of residency and a doctor’s recommendation.
Be sure to check your local laws and requirements, as they vary significantly across the country.6
What Conditions Qualify for Medical Marijuana?
The conditions that qualify you for medical marijuana depend on your state’s specific regulations. Some of the most commonly approved conditions for medical cannabis consumption:
- Chronic pain
- Cancer
- HIV/AIDS
- Severe nausea
- Muscle spasms
- Glaucoma
- Multiple sclerosis
To access medical marijuana, patients typically need certification from their physician, confirming that they have a qualifying condition. This certification is an essential part of the process and helps ensure that only those with approved medical needs can access medical cannabis. It’s also important to keep your certification updated, as many states require annual renewals to continue using medical marijuana.
Is Medical Marijuana Different From Recreational Marijuana?
The difference between medical and recreational marijuana largely depends on state regulations. While the products themselves are often similar, medical marijuana typically comes with some advantages for patients.7 These benefits include:
Higher Purchase Limits
Patients with a medical marijuana card may be allowed to buy more product per visit. Depending on the state, your certifying physician might determine how much cannabis you can purchase, ensuring you have enough to manage your symptoms.
Lower Taxes
In many states, medical marijuana is taxed at a lower rate than recreational cannabis, making it more affordable for those using it for therapeutic purposes.8 Lower taxes can significantly reduce the cost of long-term treatment for patients who rely on medical marijuana for chronic conditions.
Medical-Only Dispensaries
Some states have dispensaries that serve only medical patients. They may offer longer hours and access to in-house experts like pharmacists. For example, in New York, medical cannabis dispensaries have pharmacists on staff. For patients seeking medical cannabis in Michigan, you can find both recreational dispensaries and medical provisioning centers throughout the state.
FAQs About Medical Marijuana
Looking to start your journey with medical marijuana? Or do you have questions about obtaining a medical marijuana card? We’ve put together some answers to common questions to help you get started. And if you need more personalized advice, your friendly budtender at LivWell is always ready to assist.
Can I use my medical cannabis card in another state?
Some states have medical cannabis reciprocity, allowing patients to use their medical marijuana cards outside their home state. For instance, Michigan accepts out-of-state medical cards in their medical provisioning centers, while California and Colorado don’t. Some states even offer short-term medical marijuana cards for visitors.9
Can my doctor prescribe medical marijuana?
Doctors cannot directly prescribe medical marijuana. However, they can certify that you have a qualifying condition, allowing you to apply for a medical marijuana card. Always check your state's regulations, as requirements vary.
Can anyone get a medical marijuana card?
Not just anyone can get a medical marijuana card. You must meet your state’s requirements, including having a qualifying medical condition. Always review your state’s criteria for medical cannabis before talking to your medical health professional and applying for a medical marijuana card.
Purchasing Medical Marijuana
Once you have your medical marijuana card, the next step is finding a medical marijuana dispensary near you. Whether you need to find a dispensary in Michigan, New York, or another state, choosing a licensed and certified marijuana store ensures access to quality products and knowledgeable staff. And remember to chat with your favorite LivWell budtender if you have any medical marijuana questions.
Sources:
1. “Medical Marijuana,” Harvard Health Publishing, April 10, 2020, https://www.health.harvard.edu/blog/medical-marijuana-2018011513085
2. “What Medical Marijuana Works For,” AARP, September 3, 2019, https://www.aarp.org/health/drugs-supplements/info-2019/cannabis-for-medical-conditions.html
3. “Medical Marijuana: Benefits and Side Effects,” WebMD, January 9, 2024, https://www.webmd.com/a-to-z-guides/medical-marijuana-faq
4. “Marijuana and Cancer,” American Cancer Society, https://www.cancer.org/cancer/managing-cancer/treatment-types/complementary-and-integrative-medicine/marijuana-and-cancer.html
5. “State Medical Cannabis Laws,” NCSL, July 12, 2024, https://www.ncsl.org/health/state-medical-cannabis-laws
6. “Medical marijuana,” MedlinePlus, https://medlineplus.gov/ency/patientinstructions/000899.htm
7. “What’s the Difference Between Medical Marijuana and Recreational Weed?” GoodRx, February 13, 2024, https://www.goodrx.com/classes/cannabinoids/medicinal-vs-recreational-weed-marijuana
8. “Cannabis Taxation: Lessons Learned from U.S. States and a Blueprint for Nationwide Cannabis Tax Policy,” Tax Foundation, December 14, 2023, https://taxfoundation.org/research/all/state/cannabis-tax-revenue-reform
9. “Reciprocity,” Weedmaps, https://weedmaps.com/learn/dictionary/reciprocity
Please consume responsibly. This product may cause impairment and may be habit forming. There may be health risks associated with consumption of this product. State laws impact what dispensaries can and can’t sell to recreational customers and medical marijuana patients. Not every type of product, consumption method, dosage form, or potency mentioned on this blog will be permitted in all locations. This content is not intended as medical advice. The information provided is meant to encourage cannabis education, not replace direct patient-healthcare professional relationships. Always consult your primary care physician or other healthcare provider prior to using cannabis products for treatment of a medical condition. Any statements contained herein have not been evaluated by the Food and Drug Administration. Products referenced are not intended to diagnose, treat, cure, or prevent any disease. Products are only available where consumption of cannabis is legal.
THC may be the most famous cannabinoid, but did you know it doesn’t actually exist in the cannabis plant? It begins as a different cannabinoid called Tetrahydrocannabinolic Acid (THCA), which does not provide psychoactive effects. To convert THCA into THC, it must be decarboxylated by exposing it to heat or light.
THCA and THC may be closely related, but the characteristics and effects of these two cannabinoids differ greatly. In this article, we’ll explore the differences between THCA vs THC, the conversion process, potential benefits, and ways to use them.
Introduction to Cannabinoids
Cannabinoids are chemical compounds found in the cannabis plant. You have likely already heard of THC and CBD, but there are actually more than 500 known cannabinoids found in the cannabis plant!1 These compounds interact with the body’s endocannabinoid system to produce various effects. It’s essential to understand what cannabinoids are and how they may affect you, as they play a significant role in the therapeutic and recreational use of cannabis.
What is THCA?
THCA is a non-psychoactive cannabinoid found in raw cannabis–specifically in the plant’s smokable flowers. It is the precursor to THC and has a distinct chemical structure that prevents it from binding to cannabinoid receptors in the brain.2 This means trying to eat raw cannabis flower, stems, leaves, etc. will not provide intoxicating effects.
Cannabis flower with high levels of THCA is often consumed raw, typically through juicing, to take advantage of the potential health benefits without the psychoactive effects of THC.3
What is THC?
THC, formally known as Tetrahydrocannabinol, is the psychoactive compound in cannabis that produces an “intoxicating high.” In order to convert THCA into THC, it must be decarboxylated, or exposed to heat or light. This removes the carboxyl group from THCA, converting it into THC. When THC is consumed, it binds to the CB1 and CB2 receptors in your brain and body, producing its characteristic effects, known as a “high.”4
How is THCA converted to THC?
Decarboxylation is the key process that transforms THCA into THC. This chemical process, initiated by applying heat or through prolonged exposure to light, removes a carboxyl or carbon dioxide molecule group from THCA, transforming it into THC.16 Common methods of decarboxylation include smoking, vaping, baking, or using a decarbing device. This process is crucial in cannabis product manufacturing to ensure the cannabinoids are activated, and THC can produce its psychoactive effects.5
Here are the common methods of decarboxylation:
- Heat: Bake dried cannabis flower in an oven, vape or smoke cannabis, or use a specialized decarboxylation device.
- Time: Over time, THCA can slowly convert into THC at room temperature.
- Light: Exposure to UV light can also cause decarboxylation, though this method typically happens unintentionally when cannabis isn’t stored properly.
Key Differences Between THCA and THC
This topic is highly technical and can be confusing! Here’s an easier breakdown of the main differences between THC vs THCA:
Psychoactive Effects
The most significant difference between THCA vs THC flower lies in their psychoactive properties. THCA is non-intoxicating and doesn’t produce a “high” because it doesn’t bind to the brain’s cannabinoid receptors.6 In contrast, THC is psychoactive and responsible for the effects associated with cannabis use.7 Additionally, a full-spectrum THC product contains various cannabinoids, producing an entourage effect when consumed.
Medical Applications
THCA and THC may have therapeutic applications, but more studies are needed to verify the potential medical effects. THCA is believed to have anti-inflammatory, neuroprotective,8 and antiemetic properties. It may be beneficial for those who have arthritis or suffer from neurodegenerative diseases. On the other hand, THC may help relieve pain, stimulate appetite, and manage symptoms related to conditions like multiple sclerosis and cancer.9
Legal Status
The legal status of THC vs THCA differs significantly. THC is federally illegal in the United States, but it is allowed for medical or recreational use in some states.10 THCA, derived from hemp, is currently legal under the 2018 Farm Bill, provided it contains less than 0.3% THC. However, this is subject to change as regulations evolve.11
THCA in Raw Cannabis
THCA is abundant in raw cannabis, especially in the leaves and flowers. Consuming raw cannabis, such as through juicing or adding it to smoothies, may provide the benefits of the non-psychoactive cannabinoid without the intoxicating effects of THC. This method is popular among those looking to harness the potential therapeutic properties of cannabis without experiencing a “high.”12
THC in Cannabis Products
The presence of THCA vs THC in products you purchase from a dispensary vary based on the type of product you buy.
- Edibles, tinctures, or topicals typically only contain THC as the decarboxylation process occurred as the product was being manufactured.
- Disposable vapes and vape cartridges contain THCA, which is decarboxylated automatically by the battery’s heating element.
- Cannabis flower and marijuana concentrates contain THCA, and they require manual decarboxylation. Simply light the flower or concentrate in the consumption device of your choice to convert THCA to THC.
Potential Benefits of THCA
Unfortunately there isn’t enough cannabis research to be able to confirm its benefits, but there are a number of studies that may lead to further breakthroughs. When it comes to THCA, there are areas in which it could provide relief to patients:
- Neuroprotective - Support brain health and protect against neurodegenerative diseases like dementia.13
- Antiemetic - Reduce nausea and vomiting, which may be especially beneficial to chemotherapy patients.14
- Anticonvulsant - Reduce seizures in epilepsy.15
Frequently Asked Questions
Your favorite budtender is a great resource if you have questions. Here are a few of the most common we hear.
Can I consume THCA without experiencing psychoactive effects?
You can consume THCA, which is a non-psychoactive cannabinoid, without experiencing intoxication.
What’s the best way to preserve THCA in cannabis?
To preserve THCA, avoid exposing cannabis to heat or light, as these will trigger decarboxylation, the process that turns THCA into its active THC cousin.
How do THCA concentrations vary in different cannabis strains?
THCA concentrations vary similarly to THC levels. If a cannabis strain has a high THC content, it will also contain a lot of THCA.
Can I find products that contain only THCA?
Many products contain THCA only, and THCA diamonds are the most popular.
Choosing Between THCA and THC
Here’s a brief recap and summary about the differences between the two: THCA and THC are cannabinoids found in the cannabis plant. THC is psychoactive and is only activated when cannabis is decarboxylated. THCA is currently legal across the US pursuant to the 2018 Farm Bill, while THC is only legal for medical and recreational use in some states.
To choose between THCA and THC, consider your needs and preferences. If you're unsure, ask a budtender at your local dispensary for guidance.
Sources
1. “Cannabis (Marijuana) and Cannabinoids: What You Need to Know,” National Center for Complementary and Integrative Health, https://www.nccih.nih.gov/health/cannabis-marijuana-and-cannabinoids-what-you-need-to-know
2. “Tetrahydrocannabinolic acid (THCA),” Weedmaps, https://weedmaps.com/learn/dictionary/tetrahydrocannabinolic-acid-thca
3. “What is THCA and what are the benefits of this cannabinoid?” Leafly, September 16, 2022, https://www.leafly.com/news/cannabis-101/what-is-thca-and-what-are-the-benefits-of-this-cannabinoid
4. “Tetrahydrocannabinol (THC),” National Library of Medicine, November 12, 2023, https://www.ncbi.nlm.nih.gov/books/NBK563174/
5. “Explore THCA Flower: Effects, Benefits & More at ACS Laboratory,” ACS Laboratory, July 10, 2023, https://www.acslab.com/cannabinoids/thca-flower-effects-benefits
6. “ Affinity and Efficacy Studies of Tetrahydrocannabinolic Acid A at Cannabinoid Receptor Types One and Two,” National Library of Medicine, May 1, 20167, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510775/
7. “THCA,” Leafly, https://www.leafly.com/learn/cannabis-glossary/thca
8. “Tetrahydrocannabinolic acid as a potent PPARγ agonist with neuroprotective activity,” National Library of Medicine, November 2, 2017, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731255/
9. “Therapeutic Effects of Cannabis and Cannabinoids,” National Library of Medicine, https://www.ncbi.nlm.nih.gov/books/NBK425767/
10. “A psychoactive hemp product is available where marijuana is banned due to loophole,” NPR, August 28, 2023, https://www.npr.org/2023/08/28/1196454017/a-psychoactive-hemp-product-is-available-where-marijuana-is-banned-due-to-a-loop
11. “THCA meets legal definition of hemp, operators say - but not everyone agrees,” MJBizDaily, March 19, 2024, https://mjbizdaily.com/does-thca-adhere-to-legal-definition-of-hemp/
12. “Eating raw weed” Can it get you high?” MedicalNewsToday, February 25, 2022, https://www.medicalnewstoday.com/articles/can-you-get-high-from-eating-raw-weed
13. “The Cannabinoids, CBDA and THCA, Rescue Memory Deficits and Reduce Amyloid-Beta and Tau Pathology in an Alzheimer’s Disease-like Mouse Model,” National Library of Medicine, April 6, 2023, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095267/
14. “Tetrahydrocannabinolic acid reduces nausea-induced conditioned gaping in rats and vomiting in Suncus murinus,” National Library of Medicine, September 17, 2013, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792001/
15. “Evaluation of the Possible Anticonvulsant Effect of Δ9-Tetrahydrocannabinolic Acid in Murine Seizure Models,” National Library of Medicine, February 10, 2022, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8864425/
16. “What is THCA? Guide to One of the Acidic Cannabinoids,” Leafwell, https://leafwell.com/blog/tetrahydrocannabinolic-acid-thca-cannabinoid
Use of Marijuana Concentrate may lead to: Psychotic symptoms and/or Psychotic disorder (delusions, hallucinations, or difficulty distinguishing reality); Mental Health Symptoms/Problems; Cannabis Hyperemesis Syndrome (CHS) (uncontrolled and repetitive vomiting); Cannabis use disorder/dependence, including physical and psychological dependence. Please consume responsibly. This product may cause impairment and may be habit forming. There may be health risks associated with consumption of this product. State laws impact what dispensaries can and can’t sell to recreational customers and medical marijuana patients. Not every type of product, consumption method, dosage form, or potency mentioned on this blog will be permitted in all locations.
