THC may be the most famous cannabinoid, but did you know it doesn’t actually exist in the cannabis plant? It begins as a different cannabinoid called Tetrahydrocannabinolic Acid (THCA), which does not provide psychoactive effects. To convert THCA into THC, it must be decarboxylated by exposing it to heat or light.
THCA and THC may be closely related, but the characteristics and effects of these two cannabinoids differ greatly. In this article, we’ll explore the differences between THCA vs THC, the conversion process, potential benefits, and ways to use them.
Introduction to Cannabinoids
Cannabinoids are chemical compounds found in the cannabis plant. You have likely already heard of THC and CBD, but there are actually more than 500 known cannabinoids found in the cannabis plant!1 These compounds interact with the body’s endocannabinoid system to produce various effects. It’s essential to understand what cannabinoids are and how they may affect you, as they play a significant role in the therapeutic and recreational use of cannabis.
What is THCA?
THCA is a non-psychoactive cannabinoid found in raw cannabis–specifically in the plant’s smokable flowers. It is the precursor to THC and has a distinct chemical structure that prevents it from binding to cannabinoid receptors in the brain.2 This means trying to eat raw cannabis flower, stems, leaves, etc. will not provide intoxicating effects.
Cannabis flower with high levels of THCA is often consumed raw, typically through juicing, to take advantage of the potential health benefits without the psychoactive effects of THC.3
What is THC?
THC, formally known as Tetrahydrocannabinol, is the psychoactive compound in cannabis that produces an “intoxicating high.” In order to convert THCA into THC, it must be decarboxylated, or exposed to heat or light. This removes the carboxyl group from THCA, converting it into THC. When THC is consumed, it binds to the CB1 and CB2 receptors in your brain and body, producing its characteristic effects, known as a “high.”4
How is THCA converted to THC?
Decarboxylation is the key process that transforms THCA into THC. This chemical process, initiated by applying heat or through prolonged exposure to light, removes a carboxyl or carbon dioxide molecule group from THCA, transforming it into THC.16 Common methods of decarboxylation include smoking, vaping, baking, or using a decarbing device. This process is crucial in cannabis product manufacturing to ensure the cannabinoids are activated, and THC can produce its psychoactive effects.5
Here are the common methods of decarboxylation:
- Heat: Bake dried cannabis flower in an oven, vape or smoke cannabis, or use a specialized decarboxylation device.
- Time: Over time, THCA can slowly convert into THC at room temperature.
- Light: Exposure to UV light can also cause decarboxylation, though this method typically happens unintentionally when cannabis isn’t stored properly.
Key Differences Between THCA and THC
This topic is highly technical and can be confusing! Here’s an easier breakdown of the main differences between THC vs THCA:
Psychoactive Effects
The most significant difference between THCA vs THC flower lies in their psychoactive properties. THCA is non-intoxicating and doesn’t produce a “high” because it doesn’t bind to the brain’s cannabinoid receptors.6 In contrast, THC is psychoactive and responsible for the effects associated with cannabis use.7 Additionally, a full-spectrum THC product contains various cannabinoids, producing an entourage effect when consumed.
Medical Applications
THCA and THC may have therapeutic applications, but more studies are needed to verify the potential medical effects. THCA is believed to have anti-inflammatory, neuroprotective,8 and antiemetic properties. It may be beneficial for those who have arthritis or suffer from neurodegenerative diseases. On the other hand, THC may help relieve pain, stimulate appetite, and manage symptoms related to conditions like multiple sclerosis and cancer.9
Legal Status
The legal status of THC vs THCA differs significantly. THC is federally illegal in the United States, but it is allowed for medical or recreational use in some states.10 THCA, derived from hemp, is currently legal under the 2018 Farm Bill, provided it contains less than 0.3% THC. However, this is subject to change as regulations evolve.11
THCA in Raw Cannabis
THCA is abundant in raw cannabis, especially in the leaves and flowers. Consuming raw cannabis, such as through juicing or adding it to smoothies, may provide the benefits of the non-psychoactive cannabinoid without the intoxicating effects of THC. This method is popular among those looking to harness the potential therapeutic properties of cannabis without experiencing a “high.”12
THC in Cannabis Products
The presence of THCA vs THC in products you purchase from a dispensary vary based on the type of product you buy.
- Edibles, tinctures, or topicals typically only contain THC as the decarboxylation process occurred as the product was being manufactured.
- Disposable vapes and vape cartridges contain THCA, which is decarboxylated automatically by the battery’s heating element.
- Cannabis flower and marijuana concentrates contain THCA, and they require manual decarboxylation. Simply light the flower or concentrate in the consumption device of your choice to convert THCA to THC.
Potential Benefits of THCA
Unfortunately there isn’t enough cannabis research to be able to confirm its benefits, but there are a number of studies that may lead to further breakthroughs. When it comes to THCA, there are areas in which it could provide relief to patients:
- Neuroprotective - Support brain health and protect against neurodegenerative diseases like dementia.13
- Antiemetic - Reduce nausea and vomiting, which may be especially beneficial to chemotherapy patients.14
- Anticonvulsant - Reduce seizures in epilepsy.15
Frequently Asked Questions
Your favorite budtender is a great resource if you have questions. Here are a few of the most common we hear.
Can I consume THCA without experiencing psychoactive effects?
You can consume THCA, which is a non-psychoactive cannabinoid, without experiencing intoxication.
What’s the best way to preserve THCA in cannabis?
To preserve THCA, avoid exposing cannabis to heat or light, as these will trigger decarboxylation, the process that turns THCA into its active THC cousin.
How do THCA concentrations vary in different cannabis strains?
THCA concentrations vary similarly to THC levels. If a cannabis strain has a high THC content, it will also contain a lot of THCA.
Can I find products that contain only THCA?
Many products contain THCA only, and THCA diamonds are the most popular.
Choosing Between THCA and THC
Here’s a brief recap and summary about the differences between the two: THCA and THC are cannabinoids found in the cannabis plant. THC is psychoactive and is only activated when cannabis is decarboxylated. THCA is currently legal across the US pursuant to the 2018 Farm Bill, while THC is only legal for medical and recreational use in some states.
To choose between THCA and THC, consider your needs and preferences. If you're unsure, ask a budtender at your local dispensary for guidance.
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Sources
1. “Cannabis (Marijuana) and Cannabinoids: What You Need to Know,” National Center for Complementary and Integrative Health, https://www.nccih.nih.gov/health/cannabis-marijuana-and-cannabinoids-what-you-need-to-know
2. “Tetrahydrocannabinolic acid (THCA),” Weedmaps, https://weedmaps.com/learn/dictionary/tetrahydrocannabinolic-acid-thca
3. “What is THCA and what are the benefits of this cannabinoid?” Leafly, September 16, 2022, https://www.leafly.com/news/cannabis-101/what-is-thca-and-what-are-the-benefits-of-this-cannabinoid
4. “Tetrahydrocannabinol (THC),” National Library of Medicine, November 12, 2023, https://www.ncbi.nlm.nih.gov/books/NBK563174/
5. “Explore THCA Flower: Effects, Benefits & More at ACS Laboratory,” ACS Laboratory, July 10, 2023, https://www.acslab.com/cannabinoids/thca-flower-effects-benefits
6. “ Affinity and Efficacy Studies of Tetrahydrocannabinolic Acid A at Cannabinoid Receptor Types One and Two,” National Library of Medicine, May 1, 20167, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510775/
7. “THCA,” Leafly, https://www.leafly.com/learn/cannabis-glossary/thca
8. “Tetrahydrocannabinolic acid as a potent PPARγ agonist with neuroprotective activity,” National Library of Medicine, November 2, 2017, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731255/
9. “Therapeutic Effects of Cannabis and Cannabinoids,” National Library of Medicine, https://www.ncbi.nlm.nih.gov/books/NBK425767/
10. “A psychoactive hemp product is available where marijuana is banned due to loophole,” NPR, August 28, 2023, https://www.npr.org/2023/08/28/1196454017/a-psychoactive-hemp-product-is-available-where-marijuana-is-banned-due-to-a-loop
11. “THCA meets legal definition of hemp, operators say - but not everyone agrees,” MJBizDaily, March 19, 2024, https://mjbizdaily.com/does-thca-adhere-to-legal-definition-of-hemp/
12. “Eating raw weed” Can it get you high?” MedicalNewsToday, February 25, 2022, https://www.medicalnewstoday.com/articles/can-you-get-high-from-eating-raw-weed
13. “The Cannabinoids, CBDA and THCA, Rescue Memory Deficits and Reduce Amyloid-Beta and Tau Pathology in an Alzheimer’s Disease-like Mouse Model,” National Library of Medicine, April 6, 2023, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095267/
14. “Tetrahydrocannabinolic acid reduces nausea-induced conditioned gaping in rats and vomiting in Suncus murinus,” National Library of Medicine, September 17, 2013, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792001/
15. “Evaluation of the Possible Anticonvulsant Effect of Δ9-Tetrahydrocannabinolic Acid in Murine Seizure Models,” National Library of Medicine, February 10, 2022, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8864425/
16. “What is THCA? Guide to One of the Acidic Cannabinoids,” Leafwell, https://leafwell.com/blog/tetrahydrocannabinolic-acid-thca-cannabinoid
Use of Marijuana Concentrate may lead to: Psychotic symptoms and/or Psychotic disorder (delusions, hallucinations, or difficulty distinguishing reality); Mental Health Symptoms/Problems; Cannabis Hyperemesis Syndrome (CHS) (uncontrolled and repetitive vomiting); Cannabis use disorder/dependence, including physical and psychological dependence. Please consume responsibly. This product may cause impairment and may be habit forming. There may be health risks associated with consumption of this product. State laws impact what dispensaries can and can’t sell to recreational customers and medical marijuana patients. Not every type of product, consumption method, dosage form, or potency mentioned on this blog will be permitted in all locations.